Ontology highlight
ABSTRACT:
SUBMITTER: Serrano D
PROVIDER: S-EPMC6787248 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Serrano D D Crookshank J A JA Morgan B S BS Mueller R W RW Paré M-F MF Marandi L L Poussier P P Scott F W FW
Scientific reports 20191010 1
In a previous study we reported that prediabetic rats have a unique gene signature that was apparent even in neonates. Several of the changes we observed, including enhanced expression of pro-inflammatory genes and dysregulated UPR and metabolism genes were first observed in the liver followed by the pancreas. In the present study we investigated further early changes in hepatic innate immunity and metabolism in two models of type 1 diabetes (T1D), the BBdp rat and NOD mouse. There was a strikin ...[more]