Ontology highlight
ABSTRACT:
SUBMITTER: Whelton SP
PROVIDER: S-EPMC6788291 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Whelton Seamus P SP Mauer Andreas C AC Pencina Karol M KM Massaro Joseph M JM D'Agostino Ralph B RB Fox Caroline S CS Hoffmann Udo U Michos Erin D ED Peloso Gina M GM Dufresne Line L Engert James C JC Kathiresan Sekar S Budoff Matthew M Post Wendy S WS Thanassoulis George G O'Donnell Christopher J CJ
The American journal of cardiology 20180213 10
It is unknown if lifelong exposure to increased hemodynamic stress from an elevated resting heart rate (HR) may contribute to aortic valve calcium (AVC). We performed multivariate regression analyses using data from 1,266 Framingham Heart Study (FHS) Offspring cohort participants and 6,764 Multi-Ethnic Study of Atherosclerosis (MESA) participants. We constructed a genetic risk score (GRS) for HR using summary-level data in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ...[more]