Ontology highlight
ABSTRACT:
SUBMITTER: Basavaraja R
PROVIDER: S-EPMC6789004 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Basavaraja Raghavendra R Madusanka Senasige Thilina ST Drum Jessica N JN Shrestha Ketan K Farberov Svetlana S Wiltbank Milo C MC Sartori Roberto R Meidan Rina R
Scientific reports 20191011 1
Interferon-tau (IFNT), serves as a signal to maintain the corpus luteum (CL) during early pregnancy in domestic ruminants. We investigated here whether IFNT directly affects the function of luteinized bovine granulosa cells (LGCs), a model for large-luteal cells. Recombinant ovine IFNT (roIFNT) induced the IFN-stimulated genes (ISGs; MX2, ISG15, and OAS1Y). IFNT induced a rapid and transient (15-45 min) phosphorylation of STAT1, while total STAT1 protein was higher only after 24 h. IFNT treatmen ...[more]