Ontology highlight
ABSTRACT:
SUBMITTER: Mark MD
PROVIDER: S-EPMC6789038 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mark Melanie D MD Wollenweber Patric P Gesk Annika A Kösters Katja K Batzke Katharina K Janoschka Claudia C Maejima Takashi T Han Jing J Deneris Evan S ES Herlitze Stefan S
Communications biology 20191011
Aggressive behavior in our modern, civilized society is often counterproductive and destructive. Identifying specific proteins involved in the disease can serve as therapeutic targets for treating aggression. Here, we found that overexpression of RGS2 in explicitly serotonergic neurons augments male aggression in control mice and rescues male aggression in <i>Rgs2</i><sup><i>-/-</i></sup> mice, while anxiety is not affected. The aggressive behavior is directly correlated to the immediate early g ...[more]