Ontology highlight
ABSTRACT:
SUBMITTER: Roeles J
PROVIDER: S-EPMC6789129 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Roeles Johannes J Tsiavaliaris Georgios G
Nature communications 20191011 1
Mammalian oocytes assemble a bipolar acentriolar microtubule spindle to segregate chromosomes during asymmetric division. There is increasing evidence that actin in the spindle interior not only participates in spindle migration and positioning but also protects oocytes from chromosome segregation errors leading to aneuploidy. Here we show that actin is an integral component of the meiotic machinery that closely interacts with microtubules during all major events of human oocyte maturation from ...[more]