Ontology highlight
ABSTRACT:
SUBMITTER: Salvato MS
PROVIDER: S-EPMC6789566 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Salvato Maria S MS Domi Arban A Guzmán-Cardozo Camila C Medina-Moreno Sandra S Zapata Juan Carlos JC Hsu Haoting H McCurley Nathanael N Basu Rahul R Hauser Mary M Hellerstein Michael M Guirakhoo Farshad F
Pathogens (Basel, Switzerland) 20190828 3
Lassa fever surpasses Ebola, Marburg, and all other hemorrhagic fevers except Dengue in its public health impact. Caused by Lassa virus (LASV), the disease is a scourge on populations in endemic areas of West Africa, where reported incidence is higher. Here, we report construction, characterization, and preclinical efficacy of a novel recombinant vaccine candidate GEO-LM01. Constructed in the Modified Vaccinia Ankara (MVA) vector, GEO-LM01 expresses the glycoprotein precursor (GPC) and zinc-bind ...[more]