Ontology highlight
ABSTRACT:
SUBMITTER: Romesser PB
PROVIDER: S-EPMC6789742 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Romesser Paul B PB Kim Amanda S AS Jeong Jeho J Mayle Allison A Dow Lukas E LE Lowe Scott W SW
Proceedings of the National Academy of Sciences of the United States of America 20190924 41
Radiation-induced gastrointestinal syndrome (RIGS) is a limiting factor for therapeutic abdominopelvic radiation and is predicted to be a major source of morbidity in the event of a nuclear accident or radiological terrorism. In this study, we developed an in vivo mouse-modeling platform that enables spatial and temporal manipulation of potential RIGS targets in mice following whole-abdomen irradiation without the confounding effects of concomitant hematopoietic syndrome that occur following who ...[more]