Ontology highlight
ABSTRACT:
SUBMITTER: Maguire EM
PROVIDER: S-EPMC6789891 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Maguire Eithne M EM Pearce Stuart W A SWA Xiao Rui R Oo Aung Y AY Xiao Qingzhong Q
Pharmaceuticals (Basel, Switzerland) 20190806 3
Abdominal Aortic Aneurysm (AAA) affects 4-5% of men over 65, and Aortic Dissection (AD) is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of AAA and AD include smoking and arterial hypertension, whilst key pathophysiological features of AAA and AD include chronic inflammation, hypoxia, and large modifications to the extra cellular matrix (ECM). As it stands, only surgical methods are available for preventing aortic rupture in patients, which often pr ...[more]