Ontology highlight
ABSTRACT:
SUBMITTER: Mameishvili E
PROVIDER: S-EPMC6789925 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Mameishvili Ekaterina E Serafimidis Ioannis I Iwaszkiewicz Sara S Lesche Mathias M Reinhardt Susanne S Bölicke Nora N Büttner Maren M Stellas Dimitris D Stellas Dimitris D Papadimitropoulou Adriana A Szabolcs Matthias M Anastassiadis Konstantinos K Dahl Andreas A Theis Fabian F Efstratiadis Argiris A Gavalas Anthony A
Proceedings of the National Academy of Sciences of the United States of America 20190923 41
The presence of progenitor or stem cells in the adult pancreas and their potential involvement in homeostasis and cancer development remain unresolved issues. Here, we show that mouse centroacinar cells can be identified and isolated by virtue of the mitochondrial enzyme Aldh1b1 that they uniquely express. These cells are necessary and sufficient for the formation of self-renewing adult pancreatic organoids in an Aldh1b1-dependent manner. Aldh1b1-expressing centroacinar cells are largely quiesce ...[more]