Association between Lys198Asn polymorphism of endothelin-1 gene and ischemic stroke: A meta-analysis.

ABSTRACT:

Background

Endothelin (ET)-1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single-nucleotide polymorphism (SNP) of gene encoding ET-1 (EDN1). It is hypothesized that it might have a role in altering ET-1 and ultimately leading to vascular dysfunction and ischemic stroke. We therefore conducted a meta-analysis to investigate the association between Lys198Asn polymorphism of EDN1 gene and susceptibility of ischemic stroke.

Methods

This meta-analysis was conducted according to the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched PubMed, Google Scholar, Embase, Web of Science, J-STAGE, and China National Knowled

SUBMITTER: Nepal G 

PROVIDER: S-EPMC6790320 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature