Ontology highlight
ABSTRACT:
SUBMITTER: Chang YC
PROVIDER: S-EPMC6791367 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chang Yu-Chiuan YC Wu Jhen-Wei JW Hsieh Yi-Chi YC Huang Tzu-Han TH Liao Zih-Min ZM Huang Yi-Shan YS Mondo James A JA Montell Denise D Jang Anna C-C AC
Cell reports 20180201 8
In collective cell migration, directional protrusions orient cells in response to external cues, which requires coordinated polarity among the migrating cohort. However, the molecular mechanism has not been well defined. Drosophila border cells (BCs) migrate collectively and invade via the confined space between nurse cells, offering an in vivo model to examine how group polarity is organized. Here, we show that the front/back polarity of BCs requires Rap1, hyperactivation of which disrupts clus ...[more]