Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6791434 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Chen Jing J Zheng Dan-Xue DX Yu Xing-Juan XJ Sun Hong-Wei HW Xu Yi-Tuo YT Zhang Yao-Jun YJ Xu Jing J
Oncoimmunology 20190815 11
CD47 is known to be involved in phagocyte-mediated tumor clearance; however, its expression, clinical significance, and regulatory mechanism in hepatocellular carcinoma (HCC) remain poorly understood. In the present study, we found that upregulation of CD47 expression on tumor cells was correlated with poor overall survival and recurrence-free survival in patients with HCC. Abundance of macrophages (Mϕs) infiltration was found in CD47<sup>+</sup> tumor tissues. Mechanistic studies revealed that ...[more]