Supervised classification enables rapid annotation of cell atlases.
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ABSTRACT:
SUBMITTER: Pliner HA
PROVIDER: S-EPMC6791524 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Supervised classification enables rapid annotation of cell atlases.
Pliner Hannah A HA Shendure Jay J Trapnell Cole C
Nature methods 20190909 10
Single-cell molecular profiling technologies are gaining rapid traction, but the manual process by which resulting cell types are typically annotated is labor intensive and rate-limiting. We describe Garnett, a tool for rapidly annotating cell types in single-cell transcriptional profiling and single-cell chromatin accessibility datasets, based on an interpretable, hierarchical markup language of cell type-specific genes. Garnett successfully classifies cell types in tissue and whole organism da ...[more]
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