FOXA2 controls the cis-regulatory networks of pancreatic cancer cells in a differentiation grade-specific manner.

ABSTRACT: Differentiation of normal and tumor cells is controlled by regulatory networks enforced by lineage-determining transcription factors (TFs). Among them, TFs such as FOXA1/2 bind naïve chromatin and induce its accessibility, thus establishing new gene regulatory networks. Pancreatic ductal adenocarcinoma (PDAC) is characterized by the coexistence of well- and poorly differentiated cells at all stages of disease. How the transcriptional networks determining such massive cellular heterogeneity are established remains to be determined. We found that FOXA2, a TF controlling pancreas specification, broadly contributed to the cis-regulatory networks of PDACs. Despite being expressed in both well- and poorly differentiated PDAC cells, FOXA2 displayed extensively different genomic distributions and

SUBMITTER: Milan M 

PROVIDER: S-EPMC6792020 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature