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Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa-Endemic Areas.

ABSTRACT: The specificity of skin snips for onchocerciasis diagnoses is considered to be almost 100%. Our molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

SUBMITTER: Nana-Djeunga HC 

PROVIDER: S-EPMC6792118 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa-Endemic Areas.

Nana-Djeunga Hugues C HC   Fossuo-Thotchum Floribert F   Pion Sébastien D SD   Chesnais Cédric B CB   Kubofcik Joseph J   Mackenzie Charles D CD   Klion Amy D AD   Boussinesq Michel M   Nutman Thomas B TB   Kamgno Joseph J  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20191001 9

The specificity of skin snips for onchocerciasis diagnoses is considered to be almost 100%. Our molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas. ...[more]

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