Ontology highlight
ABSTRACT:
SUBMITTER: Sinha S
PROVIDER: S-EPMC6792153 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20190909 10
A hybrid pharmacophore approach is used to design and synthesize novel chalcone-thiazole hybrid molecules. Herein, thiazole has been hybridized with chalcone to obtain a new class of 5-LOX inhibitors. <i>In vitro</i> biological evaluation showed that most of the compounds were better 5-LOX inhibitors than the positive control, Zileuton (IC<sub>50</sub> = 1.05 ± 0.03 μM). The best compounds in the series, namely, <b>4k, 4n</b>, and <b>4v</b> (<b>4k</b>: IC<sub>50</sub> = 0.07 ± 0.02 μM, <b>4n</b> ...[more]