Ontology highlight
ABSTRACT:
SUBMITTER: Pulz R
PROVIDER: S-EPMC6792172 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Pulz Robert R Angst Daniela D Dawson Janet J Gessier Francois F Gutmann Sascha S Hersperger Rene R Hinniger Alexandra A Janser Philipp P Koch Guido G Revesz Laszlo L Vulpetti Anna A Waelchli Rudolf R Zimmerlin Alfred A Cenni Bruno B
ACS medicinal chemistry letters 20190906 10
Bruton's tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen receptor signaling in B cells and of Fc receptor signaling in mast cells and macrophages. A BTK inhibitor will likely have a positive impact on autoimmune diseases which are caused by autoreactive B cells and immune-complex driven inflammation. We report the design, optimization, and characterization of potent and selective covalent BTK in ...[more]