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Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.


ABSTRACT:

Background

Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.

Objectives

We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children.

Methods

We meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.

Results

Six CpGs were significantly associated [false discovery rate (FDR) [Formula: see text]] with prenatal [Formula: see text] and 14 with [Formula: see text] exposure. Two of the [Formula: see text] CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant ([Formula: see text]) in 7- to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent [Formula: see text] exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal [Formula: see text] and or [Formula: see text] exposure, of which two [Formula: see text] DMRs, including H19 and MARCH11, replicated in newborns.

Conclusions

Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes. https://doi.org/10.1289/EHP4522.

SUBMITTER: Gruzieva O 

PROVIDER: S-EPMC6792178 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.

Gruzieva Olena O   Xu Cheng-Jian CJ   Yousefi Paul P   Relton Caroline C   Merid Simon Kebede SK   Breton Carrie V CV   Gao Lu L   Volk Heather E HE   Feinberg Jason I JI   Ladd-Acosta Christine C   Bakulski Kelly K   Auffray Charles C   Lemonnier Nathanaël N   Plusquin Michelle M   Ghantous Akram A   Herceg Zdenko Z   Nawrot Tim S TS   Pizzi Costanza C   Richiardi Lorenzo L   Rusconi Franca F   Vineis Paolo P   Kogevinas Manolis M   Felix Janine F JF   Duijts Liesbeth L   den Dekker Herman T HT   Jaddoe Vincent W V VWV   Ruiz José L JL   Bustamante Mariona M   Antó Josep Maria JM   Sunyer Jordi J   Vrijheid Martine M   Gutzkow Kristine B KB   Grazuleviciene Regina R   Hernandez-Ferrer Carles C   Annesi-Maesano Isabella I   Lepeule Johanna J   Bousquet Jean J   Bergström Anna A   Kull Inger I   Söderhäll Cilla C   Kere Juha J   Gehring Ulrike U   Brunekreef Bert B   Just Allan C AC   Wright Rosalind J RJ   Peng Cheng C   Gold Diane R DR   Kloog Itai I   DeMeo Dawn L DL   Pershagen Göran G   Koppelman Gerard H GH   London Stephanie J SJ   Baccarelli Andrea A AA   Melén Erik E  

Environmental health perspectives 20190531 5


<h4>Background</h4>Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.<h4>Objectives</h4>We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children.<h4>Methods</h4>We meta-analyzed assoc  ...[more]

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