Dataset Information
Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China.
Ontology highlight
ABSTRACT: Background
Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. The setting of TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood.Objectives
The purpose of our study was to explore the relationships between prenatal exposure to phthalates and umbilical cord blood TL.Methods
A total of 762 mother–newborn pairs were recruited from a birth cohort study performed between November 2013 and March 2015 in Wuhan, China. Relative cord blood TL was measured using quantitative real-time polymerase chain reaction. Six phthalate metabolites were measured in urine samples acquired from pregnant women during the three trimesters. Multiple informant models were applied to estimate the associations between prenatal exposure to phthalates and cord blood TL and to evaluate potential windows of vulnerability.Results
Exposure to mono-ethyl phthalate (MEP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-butyl phthalate (MBP), and di(2-ethylhexyl) phthalate ([Formula: see text]) during the first trimester were inversely related to cord blood TL. In addition, we observed a female-specific association between maternal exposure to MEP during the first trimester and cord blood TL ([Formula: see text]). The associations between maternal exposure to MECPP, MEHHP, MEOHP, and [Formula: see text] during the first trimester and cord blood TL were consistent between males and females (all [Formula: see text]).Conclusion
This prospective study demonstrated that prenatal exposure to some phthalate metabolites were associated with shorter cord blood TL. Our results, if confirmed in other populations, may provide more evidence of adverse health outcomes of phthalate exposure and support the hypothesis that the intrauterine environment may be one of the major determinants for newborn TL. https://doi.org/10.1289/EHP4492.
SUBMITTER: Song L
PROVIDER: S-EPMC6792351 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China.
Environmental health perspectives 20190826 8
<h4>Background</h4>Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. The setting of TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood.<h4>Objectives</h4>The purpose of our study was to explore the relationships between prenatal exposure to phthalates and umbilical cord blood TL.<h4>Methods</h4>A total of 762 mother–newborn pairs were recruited from a birth cohort st ...[more]