Sam68 is required for the growth and survival of nonmelanoma skin cancer.
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ABSTRACT:
SUBMITTER: Fu K
PROVIDER: S-EPMC6792479 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Sam68 is required for the growth and survival of nonmelanoma skin cancer.
Fu Kai K Sun Xin X Xia Xue X Hobbs Ryan P RP Guo Yajuan Y Coulombe Pierre A PA Wan Fengyi F
Cancer medicine 20190822 13
Although targeting DNA repair signaling pathways has emerged as a promising therapeutic for skin cancer, the relevance of DNA damage responses (DDR) in the development and survival of nonmelanoma skin cancer (NMSC), the most common type of skin cancer, remains obscure. Here, we report that Src-associated substrate during mitosis of 68 kDa (Sam68), an early signaling molecule in DDR, is elevated in skin tumor tissues derived from NMSC patients and skin lesions from Gli2-transgenic mice. Downregul ...[more]
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