Ontology highlight
ABSTRACT:
SUBMITTER: Patel AJ
PROVIDER: S-EPMC6792668 | biostudies-literature | 1998 May
REPOSITORIES: biostudies-literature
Patel A J AJ Lauritzen I I Lazdunski M M Honoré E E
The Journal of neuroscience : the official journal of the Society for Neuroscience 19980501 9
Hypoxia and inhibitors of mitochondrial respiration impair the regulatory volume decrease (RVD) of cerebellar granule neurons after hypotonic swelling. RVD is linked to the opening of volume-regulated anion channels (VRACs). VRACs are outwardly rectifying, inactivate slowly during maintained depolarization, and are permeable to the cellular organic osmolyte taurine. Channel activation requires nonhydrolytic ATP binding and is not modulated by intracellular ADP. VRAC opening is reversibly depress ...[more]