Ontology highlight
ABSTRACT:
SUBMITTER: Arce V
PROVIDER: S-EPMC6792716 | biostudies-literature | 1998 Feb
REPOSITORIES: biostudies-literature
Arce V V Pollock R A RA Philippe J M JM Pennica D D Henderson C E CE deLapeyrière O O
The Journal of neuroscience : the official journal of the Society for Neuroscience 19980201 4
The survival of central neurons depends on multiple neurotrophic factors produced by different cell types. We demonstrate that media conditioned by muscle and Schwann cell lines show strong synergistic effects on survival of purified embryonic day 14.5 rat motoneurons in culture. Different lines of evidence implicate glial cell line-derived neurotrophic factor (GDNF) and cardiotrophin-1 (CT-1) in this synergy. Their expression in the environment of the motoneuron is compartmentalized: gdnf trans ...[more]