Ontology highlight
ABSTRACT:
SUBMITTER: Pumroy RA
PROVIDER: S-EPMC6794088 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Pumroy Ruth A RA Samanta Amrita A Liu Yuhang Y Hughes Taylor Et TE Zhao Siyuan S Yudin Yevgen Y Rohacs Tibor T Han Seungil S Moiseenkova-Bell Vera Y VY
eLife 20190930
Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of <i>Cannabis sativa</i>, is an activator of TRPV2 and also modulates other transient receptor potential (TRP) channels. Here, we determined structures of the full-length rat TRPV2 channel in apo and CBD-bound states in nanodiscs by cryo-electron microscopy. We show that CBD interacts wit ...[more]