Ontology highlight
ABSTRACT:
SUBMITTER: Bigenzahn JW
PROVIDER: S-EPMC6794158 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bigenzahn Johannes W JW Collu Giovanna M GM Kartnig Felix F Pieraks Melanie M Vladimer Gregory I GI Heinz Leonhard X LX Sedlyarov Vitaly V Schischlik Fiorella F Fauster Astrid A Rebsamen Manuele M Parapatics Katja K Blomen Vincent A VA Müller André C AC Winter Georg E GE Kralovics Robert R Brummelkamp Thijn R TR Mlodzik Marek M Superti-Furga Giulio G
Science (New York, N.Y.) 20181115 6419
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (<i>LZTR1</i>) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the <i>Drosophila LZTR1</i> ortholog <i>CG3711</i> resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 assoc ...[more]