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Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia.


ABSTRACT: The identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdomyolysis, a rare muscle disease (incidence?

SUBMITTER: Paik H 

PROVIDER: S-EPMC6794302 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia.

Paik Hyojung H   Kan Matthew J MJ   Rappoport Nadav N   Hadley Dexter D   Sirota Marina M   Chen Bin B   Manber Udi U   Cho Seong Beom SB   Butte Atul J AJ  

Scientific data 20191015 1


The identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdom  ...[more]

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