Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis.
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ABSTRACT:
SUBMITTER: Tan F
PROVIDER: S-EPMC6794434 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against <i>Enterococcus faecalis</i>.
Tan Fang F She Pengfei P Zhou Linying L Liu Yiqing Y Chen Lihua L Luo Zhen Z Wu Yong Y
Frontiers in microbiology 20191009
<i>Enterococcus faecalis</i> (<i>E. faecalis</i>), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on <i>E. faecalis</i>. In addition, CD437 exhibited synergistic effects when administered in combination with gentamici ...[more]
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