Ontology highlight
ABSTRACT:
SUBMITTER: Salas-Leal AC
PROVIDER: S-EPMC6794556 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in neurology 20191009
Parkinson's disease (PD) is the second most common movement disorder. Genetic risk factors provide information about the pathophysiology of PD that could potentially be used as biomarkers. The <i>ALDH1A1</i> gene encodes for the aldehyde dehydrogenase enzyme, which is involved in the disposal of toxic metabolites of dopamine. Due to the cytotoxic nature of aldehydes, their detoxification is essential for cellular homeostasis. It has been reported that <i>ALDH1A1</i> expression levels and activit ...[more]