Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC6795411 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Li Qiong Q Chen Yali Y Zhang Daoxiang D Grossman Julie J Li Lin L Khurana Namrata N Jiang Hongmei H Grierson Patrick M PM Herndon John J DeNardo David G DG Challen Grant A GA Liu Jingxia J Ruzinova Marianna B MB Fields Ryan C RC Lim Kian-Huat KH
JCI insight 20191003 19
Aberrant activation of the NF-κB transcription factors underlies chemoresistance in various cancer types, including colorectal cancer (CRC). Targeting the activating mechanisms, particularly with inhibitors to the upstream IκB kinase (IKK) complex, is a promising strategy to augment the effect of chemotherapy. However, clinical success has been limited, largely because of low specificity and toxicities of tested compounds. In solid cancers, the IKKs are driven predominantly by the Toll-like rece ...[more]