Dataset Information

Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles.

ABSTRACT: PURPOSE:To compare corneal tomography measurements (elevation and pachymetry) as made by two corneal tomographers: Pentacam AXL and CASIA 2. MATERIAL AND METHODS:The devices were used in a standard measuring mode. 77 normal eyes were measured five times with both devices. The data maps for anterior and posterior corneal elevation and pachymetry were exported and analyzed. Repeatability and average values were calculated for each valid data point on the exported data maps. We also calculated a corrected repeatability of the elevation data maps by removing rotation, tilt, and decentration through realignment of the elevation measurement of each eye prior to analyzing the variations in the measurement usingthe same method as for the repeatability. RESULTS:Pentacam AXL offered the better (corrected) repeatability for anterior corneal elevation measurements. CASIA 2 offered better repeatability for the pachymetry measurements. The tomographers could not be used interchangeably. The central corneal thickness was measured 9 μm ± 3 μm larger when measured with Pentacam AXL compared to CASIA 2.

SUBMITTER: Schroder S

PROVIDER: S-EPMC6795467 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles.

Schröder Simon S Langenbucher Achim A Schrecker Jens J

PloS one 20191016 10

<h4>Purpose</h4>To compare corneal tomography measurements (elevation and pachymetry) as made by two corneal tomographers: Pentacam AXL and CASIA 2.<h4>Material and methods</h4>The devices were used in a standard measuring mode. 77 normal eyes were measured five times with both devices. The data maps for anterior and posterior corneal elevation and pachymetry were exported and analyzed. Repeatability and average values were calculated for each valid data point on the exported data maps. We also ...[more]

PMID: 31618270

Similar Datasets

Project description:Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types, secretion of different trophic factors that promote a regenerative microenvironment, anti-inflammatory actions, selective migration to damaged tissues, and non-immunogenicity. MSCs are effective for the treatment of ocular surface diseases such as dry eye, corneal burns, and limbal stem cell deficiency (LSCD), both in experimental models and in humans. LSCD is a pathological condition in which damage occurs to the limbal epithelial stem cells, or their niche, that are responsible for the continuous regeneration of the corneal epithelium. If LSCD is extensive and/or severe, it usually causes corneal epithelial defects, ulceration, and conjunctival overgrowth of the cornea. These changes can result in neovascularization and corneal opacity, severe inflammation, pain, and visual loss. The effectiveness of MSCs to reduce corneal opacity, neovascularization, and inflammation has been widely studied in different experimental models of LSCD and in some clinical trials; however, the methodological disparity used in the different studies makes it hard to compare outcomes among them. In this regard, the MSC route of administration used to treat LSCD and other ocular surface diseases is an important factor. It should be efficient, minimally invasive, and safe. So far, intravenous and intraperitoneal injections, topical administration, and MSC transplantation using carrier substrata like amniotic membrane (AM), fibrin, or synthetic biopolymers have been the most commonly used administration routes in experimental models. However, systemic administration carries the risk of potential side effects and transplantation requires surgical procedures that could complicate the process. Alternatively, subconjunctival injection is a minimally invasive and straightforward technique frequently used in ophthalmology. It enables performance of local treatments using high cell doses. In this review, we provide an overview of the current status of MSC administration by subconjunctival injection, analyzing the convenience, safety, and efficacy for treatment of corneal failure due to LSCD in different experimental models. We also provide a summary of the clinical trials that have been completed, are in progress, or being planned.

Dataset Information

Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles.

Publications

Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets