Ontology highlight
ABSTRACT:
SUBMITTER: Stephen TL
PROVIDER: S-EPMC6795896 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Stephen Terri-Leigh TL Tamagnini Francesco F Piegsa Judith J Sung Katherine K Harvey Joshua J Oliver-Evans Alice A Murray Tracey K TK Ahmed Zeshan Z Hutton Michael L ML Randall Andrew A O'Neill Michael J MJ Jackson Johanna S JS
Scientific reports 20191016 1
Alzheimer's disease (AD)-associated synaptic dysfunction drives the progression of pathology from its earliest stages. Amyloid β (Aβ) species, both soluble and in plaque deposits, have been causally related to the progressive, structural and functional impairments observed in AD. It is, however, still unclear how Aβ plaques develop over time and how they progressively affect local synapse density and turnover. Here we observed, in a mouse model of AD, that Aβ plaques grow faster in the earlier s ...[more]