Ontology highlight
ABSTRACT: Background
Current fMRI-based classification approaches mostly use functional connectivity or spatial maps as input, instead of exploring the dynamic time courses directly, which does not leverage the full temporal information.Methods
Motivated by the ability of recurrent neural networks (RNN) in capturing dynamic information of time sequences, we propose a multi-scale RNN model, which enables classification between 558 schizophrenia and 542 healthy controls by using time courses of fMRI independent components (ICs) directly. To increase interpretability, we also propose a leave-one-IC-out looping strategy for estimating the top contributing ICs.Findings
Accuracies of 83·2% and 80·2% were obtained respectively for the multi-site pooling and leave-one-site-out transfer classification. Subsequently, dorsal striatum and cerebellum components contribute the top two group-discriminative time courses, which is true even when adopting different brain atlases to extract time series.Interpretation
This is the first attempt to apply a multi-scale RNN model directly on fMRI time courses for classification of mental disorders, and shows the potential for multi-scale RNN-based neuroimaging classifications. FUND: Natural Science Foundation of China, the Strategic Priority Research Program of the Chinese Academy of Sciences, National Institutes of Health Grants, National Science Foundation.
SUBMITTER: Yan W
PROVIDER: S-EPMC6796503 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yan Weizheng W Calhoun Vince V Song Ming M Cui Yue Y Yan Hao H Liu Shengfeng S Fan Lingzhong L Zuo Nianming N Yang Zhengyi Z Xu Kaibin K Yan Jun J Lv Luxian L Chen Jun J Chen Yunchun Y Guo Hua H Li Peng P Lu Lin L Wan Ping P Wang Huaning H Wang Huiling H Yang Yongfeng Y Zhang Hongxing H Zhang Dai D Jiang Tianzi T Sui Jing J
EBioMedicine 20190813
<h4>Background</h4>Current fMRI-based classification approaches mostly use functional connectivity or spatial maps as input, instead of exploring the dynamic time courses directly, which does not leverage the full temporal information.<h4>Methods</h4>Motivated by the ability of recurrent neural networks (RNN) in capturing dynamic information of time sequences, we propose a multi-scale RNN model, which enables classification between 558 schizophrenia and 542 healthy controls by using time courses ...[more]