Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6796842 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Zhang Yan Y Du Xuexiang X Liu Mingyue M Tang Fei F Zhang Peng P Ai Chunxia C Fields James K JK Sundberg Eric J EJ Latinovic Olga S OS Devenport Martin M Zheng Pan P Liu Yang Y
Cell research 20190702 8
It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LR ...[more]