Ontology highlight
ABSTRACT:
SUBMITTER: Barz B
PROVIDER: S-EPMC6797221 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Barz Bogdan B Loschwitz Jennifer J Strodel Birgit B
PLoS computational biology 20191007 10
Guanylate binding proteins (GBPs) belong to the dynamin-related superfamily and exhibit various functions in the fight against infections. The functions of the human guanylate binding protein 1 (hGBP1) are tightly coupled to GTP hydrolysis and dimerization. Despite known crystal structures of the hGBP1 monomer and GTPase domain dimer, little is known about the dynamics of hGBP1. To gain a mechanistic understanding of hGBP1, we performed sub-millisecond multi-resolution molecular dynamics simulat ...[more]