Dataset Information

Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile.

ABSTRACT:

Purpose

The Chinese Longitudinal Healthy Longevity Survey Biomarkers Cohort (Healthy Ageing and Biomarkers Cohort Study (HABCS)) was established to investigate the determinants of healthy aging and mortality among the oldest old in China. Besides collecting health status, behavioural and sociodemographic circumstances, the present study also gathers comprehensive data for the elderly by simultaneously collecting, detecting, analysing blood and urine, respectively.

Participants

HABCS is a community-based longitudinal multiwave study of older men and women aged 65 or above. Baseline survey and the follow-up surveys with replacement for deceased elderly were conducted in eight longevity areas in China, which cover the northern, middle and southern parts of China. Between 2008 and 2017, 6333 participants were included in HABCS, comprising 1385 centenarians, 1350 nonagenarians, 1294 octogenarians, 1577 younger elderly (aged 65-79).

Findings to date

We have found that higher baseline levels of (1) total cholesterol, (2) low-density lipoprotein cholesterol (LDL-C) and (3) superoxide dismutase activity were associated with greater cognitive decline. While (4) higher LDL-C level was associated with lower risk of all-cause mortality. There was a reverse association between (5) plasma vitamin D and cognitive impairment in cross-sectional and prospective study.

Future plans

We are currently exploring the relationships between various biomarkers and different outcomes such as cognitive function and mortality. This longitudinal cohort study will be continued in the future.

SUBMITTER: Lv Y

PROVIDER: S-EPMC6797363 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile.

Lv Yuebin Y Mao Chen C Yin Zhaoxue Z Li Furong F Wu Xianbo X Shi Xiaoming X

BMJ open 20191009 10

<h4>Purpose</h4>The Chinese Longitudinal Healthy Longevity Survey Biomarkers Cohort (Healthy Ageing and Biomarkers Cohort Study (HABCS)) was established to investigate the determinants of healthy aging and mortality among the oldest old in China. Besides collecting health status, behavioural and sociodemographic circumstances, the present study also gathers comprehensive data for the elderly by simultaneously collecting, detecting, analysing blood and urine, respectively.<h4>Participants</h4>HAB ...[more]

PMID: 31601581

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Dataset Information

Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile.

Purpose

Participants

Findings to date

Future plans

Publications

Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile.

Similar Datasets

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