Ontology highlight
ABSTRACT:
SUBMITTER: Krupenko NI
PROVIDER: S-EPMC6797707 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Krupenko Natalia I NI Sharma Jaspreet J Pediaditakis Peter P Fekry Baharan B Helke Kristi L KL Du Xiuxia X Sumner Susan S Krupenko Sergey A SA
Scientific reports 20191017 1
ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism highly expressed in liver, metabolizes 10-formyltetrahydrofolate to produce tetrahydrofolate (THF). This reaction might have a regulatory function towards reduced folate pools, de novo purine biosynthesis, and the flux of folate-bound methyl groups. To understand the role of the enzyme in cellular metabolism, Aldh1l1<sup>-/-</sup> mice were generated using an ES cell clone (C57BL/6N background) from KOMP repository ...[more]