Ontology highlight
ABSTRACT:
SUBMITTER: Boutry M
PROVIDER: S-EPMC6797781 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20191017
Mutations in <i>SPG11</i>, leading to loss of spatacsin function, impair the formation of membrane tubules in lysosomes and cause lysosomal lipid accumulation. However, the full nature of lipids accumulating in lysosomes and the physiological consequences of such accumulation are unknown. Here we show that loss of spatacsin inhibits the formation of tubules on lysosomes and prevents the clearance of cholesterol from this subcellular compartment. Accumulation of cholesterol in lysosomes decreases ...[more]