Ontology highlight
ABSTRACT:
SUBMITTER: Xie K
PROVIDER: S-EPMC6797801 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Xie Kang K Zhang Peng P Na Huimin H Liu Yangli Y Zhang Hong H Liu Pingsheng P
Scientific reports 20191017 1
Ectopic lipid accumulation in lipid droplets (LD) has been linked to many metabolic diseases. In this study, DHS-3::GFP was used as a LD marker in C. elegans and a forward genetic screen was carried out to find novel LD regulators. There were 140 mutant alleles identified which were divided into four phenotypic categories: enlarged, aggregated, aggregated and small, and decreased. After genetic mapping, mutations in three known LD regulatory genes (maoc-1, dhs-28, daf-22) and a peroxisome-relate ...[more]