Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China.
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ABSTRACT: Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood-CSF barrier matures. However, published studies have not reported CSF protein reference values of Chinese infants and differ in the reported rate, timing, and magnitude of this decline. The objective of this study was to determine reference intervals for CSF protein using available data of children in southern China. This retrospective study included infants who had a lumbar puncture (LP) performed in the Department of Pediatrics of Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan of an urban tertiary care children's hospital between January 1, 2008 and May 31, 2018. Infants with conditions suspected or known to cause elevated CSF protein concentrations were excluded. Of 3712 infants undergoing LP, 1043 (28.1%) met inclusion criteria. Results showed that there is an age-related decline in CSF protein concentration. The median CSF protein value was 62?mg/dL [interquartile range (IQR): 47-81?mg/dL] in infants aged 0 to 56 days (group 1). The 95th percentile values were 116?mg/dL for infants 0 to 28 days and 80?mg/dL for infants 29 to 56 days. The 95th percentile values by age category were as follows: ages 0 to 14 days, 117?mg/dL; ages 15 to 28 days, 107?mg/dL; ages 29 to 42 days, 96?mg/dL; and ages 43 to 56 days, 74?mg/dL. The median CSF protein value was 21?mg/dL (IQR: 16-31?mg/dL) in infants aged 2 months to <3 years (group 2). The 95th percentile values were 57?mg/dL for infants 2 to <6 months and 34?mg/dL for infants 6 to ?24 months. The 95th percentile values by age category were as follows: ages 2 to <3 months, 66?mg/dL; ages 3 to <4 months, 52?mg/dL; ages 4 to <5 months, 53?mg/dL; and ages 5 to <6 months, 42?mg/dL. We quantify the age-related decline in CSF protein concentrations among infants 2 years of age and younger and provide age-specific reference values. The values reported here can be used to interpret the results of LP in infants ?2 years of age.
SUBMITTER: Liu Z
PROVIDER: S-EPMC6799853 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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