Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity.
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ABSTRACT:
SUBMITTER: Mount CW
PROVIDER: S-EPMC6800000 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity.
Mount Christopher W CW Yalçın Belgin B Cunliffe-Koehler Kennedy K Sundaresh Shree S Monje Michelle M
eLife 20191018
Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary motor cortex, corpus callosum, and primary somatosensory cortex of adult mice. These inputs primarily arise from functionally-interconnecting cortical areas and thalamic nuclei, illu ...[more]
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