Ontology highlight
ABSTRACT:
SUBMITTER: Throckmorton K
PROVIDER: S-EPMC6800085 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Throckmorton Kurt K Vinnik Vladimir V Chowdhury Ratul R Cook Taylor T Chevrette Marc G MG Maranas Costas C Pfleger Brian B Thomas Michael George MG
ACS chemical biology 20190903 9
Nonribosomal peptides are important natural products biosynthesized by nonribosomal peptide synthetases (NRPSs). Adenylation (A) domains of NRPSs are highly specific for the substrate they recognize. This recognition is determined by 10 residues in the substrate-binding pocket, termed the specificity code. This finding led to the proposal that nonribosomal peptides could be altered by specificity code swapping. Unfortunately, this approach has proven, with few exceptions, to be unproductive; cha ...[more]