Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC6800152 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Park Joseph J Wetzel Isaac I Marriott Ian I Dréau Didier D D'Avanzo Carla C Kim Doo Yeon DY Tanzi Rudolph E RE Cho Hansang H
Nature neuroscience 20180627 7
Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD pathogenesis, however, remain poorly understood, partially due to the lack of relevant models that can comprehensively recapitulate multistage intercellular interactions in human AD brains. Here we present a new three-dimensional (3D) human AD triculture model using neurons, astrocytes, and microglia in a 3D microfluidic pla ...[more]