Ontology highlight
ABSTRACT:
SUBMITTER: Gardberg AS
PROVIDER: S-EPMC6800282 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Gardberg Anna S AS Huhn Annissa J AJ Cummings Richard R Bommi-Reddy Archana A Poy Florence F Setser Jeremy J Vivat Valerie V Brucelle Francois F Wilson Jonathan J
Structural dynamics (Melville, N.Y.) 20190901 5
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) catalyze the dynamic and reversible acetylation of proteins, an epigenetic regulatory mechanism associated with multiple cancers. Indeed, HDAC inhibitors are already approved in the clinic. The HAT paralogs p300 and CREB-binding protein (CBP) have been implicated in human pathological conditions including several hematological malignancies and androgen receptor-positive prostate cancer. Others have reported CoA-competitive inhibi ...[more]