Ontology highlight
ABSTRACT:
SUBMITTER: Abounahia FF
PROVIDER: S-EPMC6800408 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Clinical drug investigation 20191101 11
<h4>Background</h4>Bronchopulmonary dysplasia (BPD) is the need for oxygen therapy at 36 weeks postmenstrual age (PMA). Sildenafil has been shown to enhance the lung alveolarization and vascularization in newborn animal models after lung injury and has possible therapeutic potential for the prevention of BPD.<h4>Objective</h4>To perform a proof-of-concept, Phase II, pilot randomized, double-blind, clinical trial to study the efficacy of sildenafil in preventing BPD, in postnatal (< 24 h), extrem ...[more]