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Prophylactic Sildenafil in Preterm Infants at Risk of Bronchopulmonary Dysplasia: A Pilot Randomized, Double-Blinded, Placebo-Controlled Trial.

ABSTRACT: BACKGROUND:Bronchopulmonary dysplasia (BPD) is the need for oxygen therapy at 36 weeks postmenstrual age (PMA). Sildenafil has been shown to enhance the lung alveolarization and vascularization in newborn animal models after lung injury and has possible therapeutic potential for the prevention of BPD. OBJECTIVE:To perform a proof-of-concept, Phase II, pilot randomized, double-blind, clinical trial to study the efficacy of sildenafil in preventing BPD, in postnatal (

SUBMITTER: Abounahia FF 

PROVIDER: S-EPMC6800408 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Prophylactic Sildenafil in Preterm Infants at Risk of Bronchopulmonary Dysplasia: A Pilot Randomized, Double-Blinded, Placebo-Controlled Trial.

Abounahia Fouad F FF   Abu-Jarir Rawia R   Abounahia Mohamed F MF   Al-Badriyeh Daoud D   Abushanab Dina D   Abu-Ghalwa Mahmoud M   Mansour Ashraf A   Kurdi Bader B   Al-Rifai Hilal H  

Clinical drug investigation 20191101 11

<h4>Background</h4>Bronchopulmonary dysplasia (BPD) is the need for oxygen therapy at 36 weeks postmenstrual age (PMA). Sildenafil has been shown to enhance the lung alveolarization and vascularization in newborn animal models after lung injury and has possible therapeutic potential for the prevention of BPD.<h4>Objective</h4>To perform a proof-of-concept, Phase II, pilot randomized, double-blind, clinical trial to study the efficacy of sildenafil in preventing BPD, in postnatal (< 24 h), extrem  ...[more]

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