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Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China.

ABSTRACT: PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 1-7-4. Additionally, FJ0908 had a 100 aa deletion (aa329-428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China.

SUBMITTER: Liu J

PROVIDER: S-EPMC6800524 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China.

Liu Jiankui J Wei Chunhua C Lin Zhifeng Z Xia Wei W Ma Ying Y Dai Ailing A Yang Xiaoyan X

PeerJ 20191016

PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequenc ...[more]

PMID: 31637126

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