Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds CA
PROVIDER: S-EPMC6800620 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Reynolds Chandra A CA Smolen Andrew A Corley Robin P RP Munoz Elizabeth E Friedman Naomi P NP Rhee Soo Hyun SH Stallings Michael C MC DeFries John C JC Wadsworth Sally J SJ
Neurobiology of aging 20190418
The ε4 allele of APOE is a well-established genetic risk factor for cognitive aging and dementia, but its influence on early life cognition is unknown. Consequently, we assessed associations of APOE genotypes with cognitive performance during 7, 12, and 16 year-assessments in our ongoing Colorado Adoption/Twin Study of Lifespan behavioral development (CATSLife). In general, APOE ε4 was associated with lower Verbal, Performance, and Full Scale IQ scores during childhood and adolescence (e.g., Ful ...[more]