Ontology highlight
ABSTRACT:
SUBMITTER: Khanna R
PROVIDER: S-EPMC6800626 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Khanna Rajesh R Moutal Aubin A White Katherine A KA Chefdeville Aude A Negrao de Assis Pedro P Cai Song S Swier Vicki J VJ Bellampalli Shreya S SS Giunta Marissa D MD Darbro Benjamin W BW Quelle Dawn E DE Sieren Jessica C JC Wallace Margaret R MR Rogers Christopher S CS Meyerholz David K DK Weimer Jill M JM
Pain 20191101 11
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder resulting from germline mutations in the NF1 gene, which encodes neurofibromin. Patients experience a variety of symptoms, but pain in the context of NF1 remains largely underrecognized. Here, we characterize nociceptive signaling and pain behaviors in a miniswine harboring a disruptive NF1 mutation (exon 42 deletion). We present the first characterization of pain-related behaviors in a pig model of NF1, identifying unchang ...[more]