Ontology highlight
ABSTRACT:
SUBMITTER: Conners LM
PROVIDER: S-EPMC6800926 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Conners L M LM Betcher A A Shahinian A A Janda P P
Case reports in neurological medicine 20191007
Stiff-person syndrome (SPS) is an uncommon neurological disorder characterized by significant rigidity and muscle spasms primarily affecting the truncal and proximal musculature. Furthermore, a wide-based gait with functional impairment is generally seen. High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing. Refractory cases may be treated with intravenous immunoglobulins (IVIG), plasma exchange, or ...[more]