Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6801024 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Wang Li L Gong Yixuan Y Saci Abdel A Szabo Peter M PM Martini Alberto A Necchi Andrea A Siefker-Radtke Arlene A Pal Sumanta S Plimack Elizabeth R ER Sfakianos John P JP Bhardwaj Nina N Horowitz Amir A Farkas Adam M AM Mulholland David D Fischer Bruce S BS Oh William K WK Sharma Padmanee P Zhu Jun J Galsky Matthew D MD
European urology 20190701 5
Prior studies have demonstrated that fibroblast receptor 3 (FGFR3)-mutant urothelial cancers (UCs) are associated with decreased T-cell infiltration. As FGFR3 mutations are enriched in luminal-like UC and luminal-like UC has been shown to be relatively less responsive to PD-1/PD-L1 inhibition (checkpoint inhibition [CPI]), these data have led to the speculation that FGFR3 mutations may be causally related to poor T-cell infiltration and that UC patients harboring FGFR3 mutations may be suboptima ...[more]