Ontology highlight
ABSTRACT:
SUBMITTER: Braesel J
PROVIDER: S-EPMC6801048 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Braesel Jana J Tran Tuan Anh TA Eustáquio Alessandra S AS
Journal of industrial microbiology & biotechnology 20190515 9-10
Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation of derivatives for structure-activity relationship studies. We have previously sequenced the genomes of two diazaquinomycin-producing, actinomycete bacteria and identifi ...[more]