Dataset Information

Neurologic complications after allogeneic transplantation: a meta-analysis.

ABSTRACT:

Objective

Neurologic adverse events remain challenging complications with poor morbidity and mortality post adult allogeneic hematopoietic cell transplantation (allo-HCT) for hematologic diseases. We conducted a systematic review and meta-analysis to determine their spectrum, incidence, and impact on survival.

Methods

We searched MEDLINE, COCHRANE, EMBASE through March 2019 for all types of primary studies. Two independent reviewers screened, extracted data, and assessed risk of bias (RoB).

Results

We identified 552 eligible studies describing 57.972 patients; one randomized controlled trial, two case-control, 17 prospective, 86 retrospective cohort studies, 21 case series, and 425 case reports. RoB ranged from fair to high although case series were low-risk. The majority of studies traced infectious or drug-related neurologic manifestations. Infectious complications were present in 2.7% (95% CI 1.9-3.6) and 3.3% (95% CI 0.8-7.1) of patients in retrospective and prospective cohort studies, respectively. In retrospective studies, 3.4% (95% CI 2.1-4.9) of patients suffered from drug-related neurologic events. In prospective cohorts the equivalent incidence was 13% (95% CI 4.2-24.8). Neurologic complications had a detrimental impact on survival.

Interpretation

Our study highlights the wide spectrum and significant impact of neurologic complications on survival post allo-HCT. This systematic review summarizes existing data and provides the necessary background information for every physician involved in the management of these patients.

SUBMITTER: Gavriilaki M

PROVIDER: S-EPMC6801165 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

Neurologic complications after allogeneic transplantation: a meta-analysis.

Gavriilaki Maria M Mainou Maria M Gavriilaki Eleni E Haidich Anna-Bettina AB Papagiannopoulos Sotirios S Sakellari Ioanna I Anagnostopoulos Achilles A Kimiskidis Vasilis V

Annals of clinical and translational neurology 20190927 10

<h4>Objective</h4>Neurologic adverse events remain challenging complications with poor morbidity and mortality post adult allogeneic hematopoietic cell transplantation (allo-HCT) for hematologic diseases. We conducted a systematic review and meta-analysis to determine their spectrum, incidence, and impact on survival.<h4>Methods</h4>We searched MEDLINE, COCHRANE, EMBASE through March 2019 for all types of primary studies. Two independent reviewers screened, extracted data, and assessed risk of b ...[more]

PMID: 31560177

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Dataset Information

Neurologic complications after allogeneic transplantation: a meta-analysis.

Objective

Methods

Results

Interpretation

Publications

Neurologic complications after allogeneic transplantation: a meta-analysis.

Similar Datasets

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